PBPK Modeler en contrat à durée déterminée ou expérience internationale de volontariat (VIE)

PhinC Development is the expert partner for small to medium sized pharmaceutical or biotech companies, who need to move forward in early drug research. Thanks to a multidisciplinary team with thorough field experience, PhinC Development helps to take the best decisions concerning drug development using all existing pharmacology and pharmacometrics modelling & simulation (M&S) tools (PBPK, PopPK, PKPD and simulations). Becoming part of our team will give you hands-on experience and the chance to:

  • Work in a dynamic environment;
  • Be in a company in which innovation, people and entrepreneurship are the fundamentals of its success.

Job description

PhinC Development has an opening position for a pharmacometrician specialized in Physiologically Based Pharmacokinetics (PBPK) modelling. The position is opened for both recently graduate and junior scientist with a first experience in PBPK modelling. The candidate will be full-time dedicated to modelling activities. In the context of drug development, the use of in vitro-in vivo extrapolation (IVIVE) models has gained significant interest and physiologically based pharmacokinetics modelling is a useful tool which allows the modelling and simulation of drug-drug interaction (DDI) studies of various molecules and scenarios.

The focus will be made on the development and validation of probe substrates (inhibitors and inducers) to support model-informed drug-drug interactions studies.

Challenges 

The candidate will be responsible for:

  • PBPK model building and evaluation
  • PBPK applications (simulations and extrapolation)
  • Data analysis and simulation plan, reports writing
  • Presenting PBPK activities to internal/external teams.

Your profile

You either hold a PhD and/or a master’s degree in a relevant area (PBPK, PK/PD or PopPK modelling, pharmacology, pharmaceutical sciences or other related discipline) and have already worked with PBPK modelling software such as GastroPlus, PK-sim Simcyp or any other software. Knowledge in Phoenix WinNonLin, Monolix or NONMEem will be an asset.

You are fluent in speaking and writing English, have good communication and presentation skills, scientific rigor and motivation.

The company is located in Paris area (Massy) but also in Montreal (Canada). If you have a strong desire to further develop and apply modelling and simulation in drug development and appreciate working in teams of scientists with different backgrounds, we offer an exciting opportunity for a fixed term contract or a possible volunteering international experience (VIE) in Canada.

Contact

If you would like to be considered, please submit your CV and letter of interest to Bernard Orlandini and Virginie Gualano.

Club Phase 1
GMP - Groupe de Métabolisme et Pharmacocinétique
EUFEMED
AFSSI